Abstract
Adinazolam and its metabolites inhibit [3H]flunitrazepam binding in-vitro. The binding affinities of these compounds is significantly enhanced in the presence of 10-5 M muscimol, indicating that both adinazolam and its metabolites are benzodiazepine agonists. In-vivo metabolism of adinazolam results in the formation of active metabolites.
MeSH terms
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Animals
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Anti-Anxiety Agents / metabolism
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Anti-Anxiety Agents / pharmacology*
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Benzodiazepines / metabolism
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Benzodiazepines / pharmacology*
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Bicuculline / pharmacology
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Brain / metabolism*
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Cell Membrane / metabolism
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Flunitrazepam / metabolism
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In Vitro Techniques
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Male
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Muscimol / pharmacology
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Rats
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Rats, Inbred Strains
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Receptors, GABA-A / metabolism
Substances
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Anti-Anxiety Agents
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Receptors, GABA-A
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Benzodiazepines
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Muscimol
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Flunitrazepam
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adinazolam
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Bicuculline