Abstract
In addition to its previously characterized, six different polypeptide components, signal recognition protein--which functions in protein translocation across and integration into the endoplasmic reticulum membrane--contains a 7S RNA molecule. The RNA is closely identified with the small cytoplasmic 7SL RNA and is required for both structural and functional properties of signal recognition protein--which we therefore rename signal recognition particle.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Biological Transport
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Dogs
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Endoplasmic Reticulum / physiology*
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Macromolecular Substances
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Membrane Proteins / physiology
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Peptides / metabolism*
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Peptides / physiology
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Protein Precursors / metabolism*
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Protein Sorting Signals
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RNA / physiology*
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RNA, Small Nuclear
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Ribonucleoproteins / physiology
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Ribonucleoproteins, Small Nuclear
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Ribosomes / metabolism*
Substances
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Macromolecular Substances
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Membrane Proteins
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Peptides
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Protein Precursors
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Protein Sorting Signals
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RNA, Small Nuclear
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Ribonucleoproteins
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Ribonucleoproteins, Small Nuclear
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RNA