Percutaneous renal biopsy was performed on 300 occasions in 253 children. Adequate renal tissue was obtained in 94% of cases. Complication occurred on 26 occasions (8.7%). Seven children required blood transfusion. These results are comparable to experience of renal biopsy in the more advanced countries. Percutaneous renal biopsy is feasible in established hospitals in developing countries. Guidelines are provided for doing percutaneous renal biopsy in developing countries.