Abstract
Ketamine, an anesthetic agent endowed with several morphine-like effects, failed to displace 3H-dihydromorphine or 3H-methionine-enkephalin from opiate receptors in the rat brain synaptosomal-mitochondrial membrane preparations. Furthermore, ketamine-induced analgesia in rats was not antagonized by naloxone, suggesting that this effect is not mediated by opiate receptors.
MeSH terms
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Animals
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Binding, Competitive
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Brain / metabolism
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Dihydromorphine / metabolism
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In Vitro Techniques
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Ketamine / metabolism
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Ketamine / pharmacology*
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Male
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Mitochondria / metabolism
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Naloxone / pharmacology
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Rats
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Reaction Time / drug effects
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Receptors, Opioid / drug effects*
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Synaptosomes / metabolism
Substances
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Receptors, Opioid
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Naloxone
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Ketamine
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Dihydromorphine