Abstract
The free fraction of d-propoxyphene in the plasma of normal subjects is 0.24 +/- 0.02 (mean +/- S.D.) and is not concentration dependent in the usual therapeutic and toxic conentration range. Renal failure and relatively high concentrations of d-norpropoxyphene, the major metabolite of d-propoxyphene, have no significant effect on the plasma protein binding of d-propoxyphene.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Blood Proteins / metabolism*
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Dextropropoxyphene / analogs & derivatives
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Dextropropoxyphene / blood*
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Dextropropoxyphene / pharmacology
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Female
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Humans
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In Vitro Techniques
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Kidney / physiology*
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Kidney Failure, Chronic / blood*
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Male
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Nephrectomy
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Protein Binding / drug effects
Substances
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Blood Proteins
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Dextropropoxyphene