Abstract
The purified p21src protein of Harvey sarcoma virus shows a guanine nucleotide-binding activity and, in addition, at elevated temperature an autophosphorylating activity at a threonine residue using as phosphoryl donor GTP or dGTP but not ATP or dATP. These biochemical activities are unique among those associated with transforming proteins of RNA-containing or DNA-containing tumour viruses.
MeSH terms
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Animals
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Cell Transformation, Viral*
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Cells, Cultured
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Guanine Nucleotides / metabolism*
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Mice
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Oncogene Protein p21(ras)
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Phosphoproteins / metabolism
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Phosphorylation
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Protein Kinases / metabolism*
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Sarcoma Viruses, Murine / metabolism*
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Sarcoma, Experimental / metabolism
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Substrate Specificity
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Threonine / metabolism
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Viral Proteins / metabolism*
Substances
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Guanine Nucleotides
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Phosphoproteins
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Viral Proteins
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Threonine
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Protein Kinases
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Oncogene Protein p21(ras)