Abstract
Fusions between the mouse mammary tumour virus long terminal repeat and a mouse dihydrofolate reductase cDNA have been constructed in a SV40 vector. When these plasmids are transferred into recipient cells, the production of dihydrofolate reductase is regulated by glucocorticoid hormones. These results define a hormonally responsive region of the viral genome.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Base Sequence
-
Cell Transformation, Viral / drug effects*
-
Cloning, Molecular*
-
DNA, Recombinant / metabolism
-
Glucocorticoids / pharmacology*
-
Mammary Tumor Virus, Mouse / drug effects
-
Mammary Tumor Virus, Mouse / enzymology
-
Mammary Tumor Virus, Mouse / genetics*
-
Mice
-
Plasmids / drug effects*
-
Tetrahydrofolate Dehydrogenase / genetics*
Substances
-
DNA, Recombinant
-
Glucocorticoids
-
Tetrahydrofolate Dehydrogenase