Abstract
Self-associating IgG rheumatoid factors isolated from three patients with rheumatoid arthritis activated human monocytes to release prostaglandin E2 as well as a previously described mononuclear cell factor, which stimulates human synovial cells to release additional prostaglandin E2 and collagenase. Thus, the immune complexes composed of self-associating IgG rheumatoid factors can contribute to the processes that destroy cartilage and bone in patients with rheumatoid arthritis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Humans
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Immunoglobulin G / pharmacology*
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Microbial Collagenase / biosynthesis*
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Monocytes / metabolism*
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Monokines
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Prostaglandins E / biosynthesis
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Prostaglandins E / metabolism*
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Proteins / metabolism*
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Rheumatoid Factor / pharmacology*
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Synovial Membrane / cytology
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Synovial Membrane / metabolism*
Substances
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Immunoglobulin G
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Monokines
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Prostaglandins E
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Proteins
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Rheumatoid Factor
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Microbial Collagenase