Abstract
Ten hemangioblastomas of the central nervous system were examined by an immunoperoxidase technique for glial fibrillary acidic protein (GFAP), S-100 protein, and Factor VIII-related antigen to determine the origin of the stromal cells. In seven cases scattered stromal cells were positive for GFAP, and eight cases showed variable numbers of S-100 protein-positive cells. These positive cells were present throughout the tumors. S-100 protein-positive stromal cells corresponded to GFAP-positive cells, but the former were more numerous than the latter. Staining for Factor VIII-related antigen was negative in stromal cells, except in endothelial cells lining capillaries. It was suggested that stromal cells of capillary hemangioblastomas are composed by heterogeneous cell populations.
MeSH terms
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Adult
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Antigens / analysis
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Antigens, Neoplasm / analysis
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Cerebellar Neoplasms / pathology
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Cerebral Ventricle Neoplasms / pathology
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Factor VIII / analysis
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Factor VIII / immunology
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Female
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Glial Fibrillary Acidic Protein
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Hemangiosarcoma / immunology
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Hemangiosarcoma / metabolism
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Hemangiosarcoma / pathology*
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Histocytochemistry
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Humans
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Immunoenzyme Techniques
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Intermediate Filament Proteins / analysis
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Male
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Middle Aged
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Neoplasm Proteins / analysis
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Nervous System Neoplasms / immunology
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Nervous System Neoplasms / metabolism
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Nervous System Neoplasms / pathology*
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S100 Proteins / analysis
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von Willebrand Factor
Substances
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Antigens
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Antigens, Neoplasm
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Glial Fibrillary Acidic Protein
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Intermediate Filament Proteins
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Neoplasm Proteins
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S100 Proteins
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von Willebrand Factor
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Factor VIII