Molecular cloning of a cDNA encoding human antihaemophilic factor

Nature. 1984 Nov;312(5992):342-7. doi: 10.1038/312342a0.

Abstract

A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens / genetics
  • Cloning, Molecular
  • DNA / genetics
  • Factor VIII / genetics*
  • Factor VIII / immunology
  • Gene Expression Regulation
  • Genes
  • Humans
  • Molecular Weight
  • RNA, Messenger / genetics
  • Swine

Substances

  • Antigens
  • RNA, Messenger
  • Factor VIII
  • DNA

Associated data

  • GENBANK/K01740