Abstract
A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens / genetics
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Cloning, Molecular
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DNA / genetics
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Factor VIII / genetics*
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Factor VIII / immunology
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Gene Expression Regulation
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Genes
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Humans
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Molecular Weight
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RNA, Messenger / genetics
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Swine
Substances
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Antigens
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RNA, Messenger
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Factor VIII
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DNA