[Bioavailability of cyproterone acetate after oral and intramuscular application in men (author's transl)]

Urol Int. 1980;35(6):381-5. doi: 10.1159/000280353.
[Article in German]

Abstract

Cyproterone acetate was administered orally and intramuscularly to 5 male patients. The level of the active substance in plasma was monitored at intervals during the period of application using radioimmunoassay specific for cyproterone acetate. The areas under the drug level curves were similar after oral and intramuscular application of cyproterone acetate when taking into consideration the different doses used. Accordingly, cyproterone acetate is not dependent upon a "first-pass" effect. The bioavailability of the active substance was complete following oral application.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Administration, Oral
  • Aged
  • Biological Availability
  • Cyproterone / administration & dosage
  • Cyproterone / analogs & derivatives*
  • Cyproterone / blood
  • Cyproterone Acetate
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / drug therapy*
  • Radioimmunoassay

Substances

  • Cyproterone Acetate
  • Cyproterone