Abstract
Alkyl lysophospholipids (ALP) are synthetic analogs of the naturally occurring 2-lysophosphatidylcholine. The effect of ALP on the proliferation of 22 different gynecologic malignant tumors in humans was studied in vitro. ALP caused progressive death of tumor cells over 24-96 hours. In addition, tumor specimens from the tested human tumors were xenotransplanted into NMRI nude mice. ALP induced a highly significant retardation of the in vivo growing human tumors. Neither oral nor iv administration of these compounds caused any recognizable side effects.
MeSH terms
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Adenocarcinoma / drug therapy
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Animals
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Carcinoma / drug therapy
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Female
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Genital Neoplasms, Female / drug therapy*
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Humans
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In Vitro Techniques
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Lysophosphatidylcholines / therapeutic use*
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Lysophospholipids
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Mice
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Mice, Nude
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Neoplasm Transplantation
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Neoplasms, Experimental / drug therapy
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Ovarian Neoplasms / drug therapy
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Phospholipids / therapeutic use*
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Sarcoma / drug therapy
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Teratoma / drug therapy
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Transplantation, Heterologous
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Uterine Cervical Neoplasms / drug therapy
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Uterine Neoplasms / drug therapy
Substances
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Lysophosphatidylcholines
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Lysophospholipids
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Phospholipids