The biopsy service at Indiana University School of Dentistry, Department of Oral Pathology, accessioned 464 cases of giant cell fibroma from February, 1971, until May, 1980. From a study of these cases, it appears that the giant cell fibroma is a distinctive lesion with a characteristic age distribution, location, sex incidence, and histologic appearance. Clinically, the giant cell fibroma presents as an asymptomatic, papillary, pedunculated lesion, commonly regarded as a papilloma. It is fairly common in young persons and usually occurs on the gingiva. No sex predilection has been noted, and simple surgical excision appears to be the treatment of choice.