Death from acute pancreatitis. M.R.C. multicentre trial of glucagon and aprotinin

Lancet. 1977 Sep 24;2(8039):632-5.

Abstract

The influence of glucagon and aprotinin ('Trasylol') on the death-rate of acute pancreatitis has been studied in a randomised double-blind multicentre trial. The death-rate in 257 patients was 11%. In the doses used neither drug was found to diminish the risk of death.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Adult
  • Age Factors
  • Aged
  • Aprotinin / administration & dosage
  • Aprotinin / therapeutic use*
  • Clinical Trials as Topic
  • Drug Administration Schedule
  • Drug Evaluation
  • Drug Therapy, Combination
  • Female
  • Glucagon / administration & dosage
  • Glucagon / therapeutic use*
  • Humans
  • Infusions, Parenteral
  • Male
  • Middle Aged
  • Pancreatitis / drug therapy
  • Pancreatitis / etiology
  • Pancreatitis / mortality*
  • Placebos
  • Sex Ratio

Substances

  • Placebos
  • Glucagon
  • Aprotinin