Following a prolonged bite by a large specimen of the wandering garter snake (Thamnophis elegans vagrans), symptoms of envenomation rapidly developed. Swelling, edema, pain, and localized hemorrhaging occurred but without the subsequent onset of systemic manifestations. The bite recipient was carefully examined and the evolution of poisoning monitored. Depending upon duration of the bite and inclination of the snake, members of this species are capable of occasionally causing mild envenomation in humans, inducing localized poisoning not unlike that seen following bites by small Crotalidae (pit vipers).