Abstract
Src-related cytoplasmic PTKs are physically and functionally associated with cell surface receptors and are involved in signal transduction. In this paper we report the identification of src-related proteins p59fyn, pp60c-src and p62yes in human microvascular endothelial cells cultured from normal human skin and their physical association with the thrombospondin receptor CD36. Such an association represents a potential signalling pathway by which thrombospondin may regulate angiogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, CD / metabolism*
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Blotting, Western
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CD36 Antigens
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CSK Tyrosine-Protein Kinase
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Cells, Cultured
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Endothelium, Vascular / cytology
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Endothelium, Vascular / immunology*
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Humans
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Protein-Tyrosine Kinases / metabolism*
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-fyn
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Proto-Oncogene Proteins c-yes
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Proto-Oncogene Proteins pp60(c-src) / metabolism*
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Skin / cytology
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Skin / immunology*
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src-Family Kinases*
Substances
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Antigens, CD
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CD36 Antigens
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Proto-Oncogene Proteins
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Protein-Tyrosine Kinases
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CSK Tyrosine-Protein Kinase
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FYN protein, human
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Proto-Oncogene Proteins c-fyn
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Proto-Oncogene Proteins c-yes
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Proto-Oncogene Proteins pp60(c-src)
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src-Family Kinases
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CSK protein, human