Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells

FEBS Lett. 1994 Aug 29;351(1):41-4. doi: 10.1016/0014-5793(94)00814-0.

Abstract

Src-related cytoplasmic PTKs are physically and functionally associated with cell surface receptors and are involved in signal transduction. In this paper we report the identification of src-related proteins p59fyn, pp60c-src and p62yes in human microvascular endothelial cells cultured from normal human skin and their physical association with the thrombospondin receptor CD36. Such an association represents a potential signalling pathway by which thrombospondin may regulate angiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / metabolism*
  • Blotting, Western
  • CD36 Antigens
  • CSK Tyrosine-Protein Kinase
  • Cells, Cultured
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / immunology*
  • Humans
  • Protein-Tyrosine Kinases / metabolism*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-fyn
  • Proto-Oncogene Proteins c-yes
  • Proto-Oncogene Proteins pp60(c-src) / metabolism*
  • Skin / cytology
  • Skin / immunology*
  • src-Family Kinases*

Substances

  • Antigens, CD
  • CD36 Antigens
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • CSK Tyrosine-Protein Kinase
  • FYN protein, human
  • Proto-Oncogene Proteins c-fyn
  • Proto-Oncogene Proteins c-yes
  • Proto-Oncogene Proteins pp60(c-src)
  • src-Family Kinases
  • CSK protein, human