Human AQP2 and MIP genes, two members of the MIP family, map within chromosome band 12q13 on the basis of two-color FISH

Cytogenet Cell Genet. 1995;68(1-2):45-8. doi: 10.1159/000133885.

Abstract

The human AQP2 (collecting duct water channel, aquaporin 2) gene encodes a 271 amino acid protein and is a member of the MIP (major intrinsic protein of lens fiber) gene family. Using two-color fluorescence in situ hybridization on high-resolution R-banded chromosomes and human genomic DNA clones for AQP2 and MIP as probes, we found that both genes mapped closely within the human chromosome region 12q13.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aquaporin 2
  • Aquaporin 6
  • Aquaporins*
  • Bacterial Proteins / genetics*
  • Cells, Cultured
  • Chromosome Banding
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • Hominidae / genetics*
  • Humans
  • Immunophilins*
  • In Situ Hybridization, Fluorescence / methods
  • Ion Channels / genetics*
  • Lymphocytes / cytology
  • Lymphocytes / metabolism
  • Membrane Proteins / genetics*
  • Multigene Family*
  • Peptidylprolyl Isomerase*

Substances

  • AQP2 protein, human
  • Aquaporin 2
  • Aquaporin 6
  • Aquaporins
  • Bacterial Proteins
  • Ion Channels
  • Membrane Proteins
  • Immunophilins
  • Peptidylprolyl Isomerase