Abstract
Canalicular adenoma is a newly recognized salivary gland adenoma that may be confused with malignant salivary gland tumors. To better characterize this neoplasm, six examples were investigated with a panel of immunohistochemistry antibodies including anti-keratin (AE1/AE3), anti-epithelial membrane antigen, anti-carcinoembryonic antigen, anti-vimentin, anti-S-100, anti-muscle specific actin, and anti-glial fibrillary acid protein. All canalicular adenomas stained in a similar fashion showing positive staining with anti-keratin, anti-vimentin, and anti-S-100 (6 of 6 cases each). Rare focal staining with anti-epithelial membrane antigen and anti-glial fibrillary acid protein was noted (1 of 6 cases each). This immunohistochemistry staining pattern was compared with those of ameloblastoma, polymorphous low-grade adenocarcinoma, and adenoid cystic carcinoma. Immunohistochemistry may be useful in the distinction of canalicular adenoma from other salivary gland tumors.
MeSH terms
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Actins / analysis
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Aged
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Ameloblastoma / chemistry
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Ameloblastoma / pathology
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Antibodies, Monoclonal
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Carcinoembryonic Antigen / analysis
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Carcinoma, Adenoid Cystic / chemistry
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Carcinoma, Adenoid Cystic / pathology
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Carcinoma, Ductal, Breast / chemistry
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Carcinoma, Ductal, Breast / pathology
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Carcinoma, Lobular / chemistry
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Carcinoma, Lobular / pathology
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Diagnosis, Differential
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Female
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Glial Fibrillary Acidic Protein / analysis
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Humans
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Immunoenzyme Techniques
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Keratins / analysis
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Lip Neoplasms / chemistry*
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Lip Neoplasms / pathology
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Male
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Membrane Glycoproteins / analysis
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Middle Aged
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Mouth Mucosa / chemistry
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Mouth Mucosa / pathology
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Mucin-1
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Mucins / analysis
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Neoplasm Proteins / analysis*
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S100 Proteins / analysis
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Salivary Gland Neoplasms / chemistry*
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Salivary Gland Neoplasms / pathology
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Salivary Glands, Minor / chemistry*
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Salivary Glands, Minor / pathology
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Vimentin / analysis
Substances
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Actins
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Antibodies, Monoclonal
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Carcinoembryonic Antigen
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Glial Fibrillary Acidic Protein
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Membrane Glycoproteins
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Mucin-1
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Mucins
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Neoplasm Proteins
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S100 Proteins
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Vimentin
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Keratins