Absence of infection in breast-fed infants born to hepatitis C virus-infected mothers

H H Lin; J H Kao; H Y Hsu; Y H Ni; M H Chang; S C Huang; L H Hwang; P J Chen; D S Chen

doi:10.1016/s0022-3476(95)70356-x

Absence of infection in breast-fed infants born to hepatitis C virus-infected mothers

J Pediatr. 1995 Apr;126(4):589-91. doi: 10.1016/s0022-3476(95)70356-x.

Authors

H H Lin¹, J H Kao, H Y Hsu, Y H Ni, M H Chang, S C Huang, L H Hwang, P J Chen, D S Chen

Affiliation

¹ Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Republic of China.

PMID: 7535353
DOI: 10.1016/s0022-3476(95)70356-x

Abstract

The role of breast-feeding in perinatal transmission of hepatitis C virus (HCV) was explored in 15 HCV-infected mothers and their infants. The 15 carrier mothers had anti-HCV titers ranging from 1:80 to 1:40,000 and also had HCV-ribonucleic acid with concentrations ranging from 10(4) to 2.5 x 10(8) copies/ml. Both anti-HCV antibody and HCV-ribonucleic acid were present in colostral samples in much lower levels, but none of the 11 breast-fed infants had evidence of HCV infection for up to 1 year of age. Thus breast-feeding seems safe for these infants.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breast Feeding*
Carrier State / transmission*
Colostrum / virology*
Female
Hepacivirus / genetics
Hepacivirus / immunology
Hepacivirus / isolation & purification*
Hepatitis Antibodies / analysis
Hepatitis C / blood
Hepatitis C / transmission*
Hepatitis C Antibodies
Humans
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical*
Pregnancy
Pregnancy Complications, Infectious*
RNA, Viral / analysis

Substances

Hepatitis Antibodies
Hepatitis C Antibodies
RNA, Viral