The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA

K Nagai; C Oubridge; N Ito; J Avis; P Evans

doi:10.1016/s0968-0004(00)89024-6

The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA

Trends Biochem Sci. 1995 Jun;20(6):235-40. doi: 10.1016/s0968-0004(00)89024-6.

Authors

K Nagai¹, C Oubridge, N Ito, J Avis, P Evans

Affiliation

¹ MRC Laboratory of Molecular Biology, Cambridge, UK.

PMID: 7543225
DOI: 10.1016/s0968-0004(00)89024-6

Abstract

The RNP domain is found in a number of proteins involved in processing and transport of mRNA precursors. The crystal structure of a complex between the U1A spliceosomal protein and its cognate RNA hairpin at 1.92 A resolution reveals the molecular basis of sequence-specific RNA recognition by the RNP domain.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Sequence
Base Sequence
Biological Transport
Molecular Sequence Data
Protein Structure, Tertiary*
RNA / metabolism*
RNA Processing, Post-Transcriptional*
RNA-Binding Proteins / chemistry*
Ribonucleoproteins / chemistry*

Substances

RNA-Binding Proteins
Ribonucleoproteins
RNA