Activated protein C resistance in a neonate with venous thrombosis

E Kodish; C Potter; N E Kirschbaum; P A Foster

doi:10.1016/s0022-3476(95)70131-1

Activated protein C resistance in a neonate with venous thrombosis

J Pediatr. 1995 Oct;127(4):645-8. doi: 10.1016/s0022-3476(95)70131-1.

Authors

E Kodish¹, C Potter, N E Kirschbaum, P A Foster

Affiliation

¹ Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

PMID: 7562293
DOI: 10.1016/s0022-3476(95)70131-1

Abstract

A term infant had a life-threatening inferior venal caval thrombosis during the first 24 hours of life. The plasma from the infant and his mother was found to be resistant to activated protein C and to be heterozygous for the factor V mutation (FV Leiden) associated with this disorder. The presence of this hereditary disorder should be considered in infants with thrombosis and in infants with conditions predisposing them to thrombosis.

Publication types

Case Reports

MeSH terms

Antithrombin III
Factor V / analysis
Factor V / genetics
Gene Amplification
Genotype
Humans
Infant, Newborn*
Male
Mutagenesis
Partial Thromboplastin Time
Pedigree
Polymerase Chain Reaction
Protein C / analysis*
Prothrombin Time
Thrombophlebitis / diagnosis*
Thrombophlebitis / genetics*

Substances

Protein C
Antithrombin III
Factor V