Computer prediction and experimental validation of cytochrome P4502D6-dependent oxidation of GBR 12909

Drug Metab Dispos. 1995 Jun;23(6):667-9.
No abstract available

MeSH terms

  • Computer Simulation*
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 Enzyme System / metabolism*
  • Dopamine Uptake Inhibitors / metabolism*
  • Mixed Function Oxygenases / metabolism*
  • Oxidation-Reduction
  • Piperazines / metabolism*
  • Predictive Value of Tests
  • Reproducibility of Results
  • Structure-Activity Relationship

Substances

  • Dopamine Uptake Inhibitors
  • Piperazines
  • Cytochrome P-450 Enzyme System
  • vanoxerine
  • Mixed Function Oxygenases
  • Cytochrome P-450 CYP2D6