Cowden syndrome (multiple hamartoma syndrome)

Dermatol Clin. 1995 Jan;13(1):27-31.

Abstract

Cowden syndrome (multiple hamartoma syndrome) is characterized by multiple facial papules, gingival papillomas, acral keratoses, and other hamartomatous lesions. There is a high incidence of breast and thyroid carcinoma. Recognition of this syndrome may lead to the early diagnosis of cancer.

Publication types

  • Review

MeSH terms

  • Adult
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Child
  • Facial Neoplasms / genetics
  • Facial Neoplasms / pathology
  • Female
  • Gingival Neoplasms / genetics
  • Gingival Neoplasms / pathology
  • Hamartoma Syndrome, Multiple / genetics
  • Hamartoma Syndrome, Multiple / pathology*
  • Hamartoma Syndrome, Multiple / physiopathology
  • Humans
  • Keratosis / genetics
  • Keratosis / pathology
  • Male
  • Neoplasms, Multiple Primary / genetics
  • Neoplasms, Multiple Primary / pathology
  • Papilloma / genetics
  • Papilloma / pathology
  • Thyroid Neoplasms / genetics
  • Thyroid Neoplasms / pathology