Abstract
Cowden syndrome (multiple hamartoma syndrome) is characterized by multiple facial papules, gingival papillomas, acral keratoses, and other hamartomatous lesions. There is a high incidence of breast and thyroid carcinoma. Recognition of this syndrome may lead to the early diagnosis of cancer.
MeSH terms
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Adult
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Breast Neoplasms / genetics
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Breast Neoplasms / pathology
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Child
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Facial Neoplasms / genetics
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Facial Neoplasms / pathology
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Female
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Gingival Neoplasms / genetics
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Gingival Neoplasms / pathology
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Hamartoma Syndrome, Multiple / genetics
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Hamartoma Syndrome, Multiple / pathology*
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Hamartoma Syndrome, Multiple / physiopathology
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Humans
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Keratosis / genetics
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Keratosis / pathology
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Male
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Neoplasms, Multiple Primary / genetics
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Neoplasms, Multiple Primary / pathology
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Papilloma / genetics
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Papilloma / pathology
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Thyroid Neoplasms / genetics
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Thyroid Neoplasms / pathology