Abstract
We have developed a practical synthesis of N-hydroxy-N'-phenyloctanediamide from the methyl ester of suberanilic acid. It provides the product in high yield and purity with a simple purification process. We have found that at 10(-5) M it has a dramatic effect on T/5 AXC/SSh rat prostate cancer cells in vitro. It is a potent inhibitor of cell proliferation and it changes the cell morphology to resemble nonmalignant cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amides / chemical synthesis*
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Amides / pharmacology
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Division / drug effects
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Drug Screening Assays, Antitumor
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Hydroxamic Acids
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Male
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Prostatic Neoplasms / drug therapy*
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Rats
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Tumor Cells, Cultured
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Vorinostat
Substances
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Amides
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Antineoplastic Agents
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Hydroxamic Acids
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Vorinostat