Abstract
Daily administration of tryptophol to laboratory rodents resulted in significantly depressed antibody production of heterologous red blood cell challenge, did not alter cellular-mediated responses to oxazalone. These results suggest that trypanosome-produced tryptophol may account for the immunodepression observed during trypanosomiasis.
MeSH terms
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ABO Blood-Group System
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Animals
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Antibody Formation / drug effects*
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Arvicolinae
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Carcinoma, Ehrlich Tumor
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Erythrocytes / immunology
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Humans
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Immunosuppression Therapy*
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Indoles / pharmacology*
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Mice
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Oxazolone / immunology
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Spleen / drug effects
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Spleen / metabolism
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Thymidine / metabolism
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Trypanosoma*
Substances
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ABO Blood-Group System
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Indoles
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Oxazolone
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tryptophol
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Thymidine