The effects of tryptophol on immune responses and it implications toward trypanosome-induced immunosuppression

Experientia. 1976 May 15;32(5):645-7. doi: 10.1007/BF01990212.

Abstract

Daily administration of tryptophol to laboratory rodents resulted in significantly depressed antibody production of heterologous red blood cell challenge, did not alter cellular-mediated responses to oxazalone. These results suggest that trypanosome-produced tryptophol may account for the immunodepression observed during trypanosomiasis.

MeSH terms

  • ABO Blood-Group System
  • Animals
  • Antibody Formation / drug effects*
  • Arvicolinae
  • Carcinoma, Ehrlich Tumor
  • Erythrocytes / immunology
  • Humans
  • Immunosuppression Therapy*
  • Indoles / pharmacology*
  • Mice
  • Oxazolone / immunology
  • Spleen / drug effects
  • Spleen / metabolism
  • Thymidine / metabolism
  • Trypanosoma*

Substances

  • ABO Blood-Group System
  • Indoles
  • Oxazolone
  • tryptophol
  • Thymidine