The fungal cell wall as a drug target

Trends Microbiol. 1995 Mar;3(3):98-104. doi: 10.1016/s0966-842x(00)88890-3.

Abstract

Fungal infections are increasingly common and, in certain vulnerable patients, can be serious and even life threatening. The fungal cell wall, a structure with no mammalian counterpart, presents an attractive therapeutic target. Inhibitors of the synthesis of one cell-wall component, beta-(1,3)-glucan, are currently under development as antifungal and antipneumocystis agents.

Publication types

  • Review

MeSH terms

  • Antifungal Agents / pharmacology*
  • Carbohydrate Sequence
  • Cell Wall / drug effects*
  • Chitin / biosynthesis
  • Chitin Synthase / antagonists & inhibitors*
  • Glucans / biosynthesis
  • Glucosyltransferases / antagonists & inhibitors*
  • Molecular Sequence Data
  • Mycoses / drug therapy*
  • beta-Glucans*

Substances

  • Antifungal Agents
  • Glucans
  • beta-Glucans
  • Chitin
  • beta-1,3-glucan
  • Glucosyltransferases
  • glucan synthase
  • Chitin Synthase