Abstract
Complementation of a temperature sensitive mutant of the yeast Saccharomyces cerevisiae resulted in the isolation of PTF1 (processing/termination factor 1), an essential gene encoding a putative 3'-end processing or transcription termination factor of pre-mRNAs. Ptf1p shows significant homology to a newly discovered family of PPIases. This family is characterized by its insensitivity to immunosuppressive drugs and the lack of homology with cyclophilins and FK-506 binding proteins [Rahfeld et al. (1994) FEBS Lett. 352, 180-184]. Should Ptf1p display PPIase activity, it would be the first characterized, eukaryotic member of this putative family, which is essential for growth.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Isomerases / biosynthesis*
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Amino Acid Isomerases / chemistry*
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Amino Acid Isomerases / genetics
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Amino Acid Sequence
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Base Sequence
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Carrier Proteins / chemistry*
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Carrier Proteins / genetics
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DNA, Fungal / chemistry
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DNA, Fungal / metabolism
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Endodeoxyribonucleases / chemistry
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Genes, Fungal*
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Genetic Complementation Test
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Molecular Sequence Data
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Mutagenesis
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NIMA-Interacting Peptidylprolyl Isomerase
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Open Reading Frames
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Peptidylprolyl Isomerase
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Restriction Mapping
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins
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Sequence Deletion
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Sequence Homology, Amino Acid
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Temperature
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Transcription Factors / biosynthesis*
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Transcription Factors / chemistry*
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Transcription Factors / genetics
Substances
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Carrier Proteins
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DNA, Fungal
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NIMA-Interacting Peptidylprolyl Isomerase
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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Endodeoxyribonucleases
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Amino Acid Isomerases
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ESS1 protein, S cerevisiae
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Peptidylprolyl Isomerase