Inhaled mycotoxins lead to acute renal failure

Nephrol Dial Transplant. 1994:9 Suppl 4:116-20.

Abstract

Mysterious deaths of archeologists after opening Egyptian tombs have been suspected, but never proved, to be secondary to inhalation of mycotoxin. We observed a case of acute renal failure (ARF) due to inhalation of ochratoxin A produced by a mould of the species Aspergillus ochraceus. After working 8 h in a granary closed for several months, a farmer and his wife suffered respiratory distress; the woman developed non-oliguric ARF and biopsy revealed tubulonecrosis. A strain of Aspergillus ochraceus producing ochratoxin was isolated from the wheat.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / pathology
  • Administration, Inhalation
  • Agriculture
  • Animals
  • Aspergillus ochraceus / isolation & purification
  • Disease Models, Animal
  • Female
  • Guinea Pigs
  • Humans
  • Kidney / pathology
  • Liver / pathology
  • Microscopy, Electron
  • Middle Aged
  • Occupational Diseases / etiology
  • Occupational Diseases / pathology
  • Ochratoxins / administration & dosage
  • Ochratoxins / adverse effects*
  • Ochratoxins / isolation & purification
  • Rabbits
  • Triticum / microbiology

Substances

  • Ochratoxins
  • ochratoxin A