Abstract
A gene (minK) that encodes a minimal potassium channel has been cloned recently. We describe in this paper a human minK sequence which differs from the original sequence with a single A-->G at position 112. This resulted in a change from a Ser codon (AGT) to a Gly codon (GGT) and created a new MspAI restriction site. Of the 32 alleles from 16 subjects studied, 25 had this newly discovered sequence and 7 had the previously described sequence.
Publication types
-
Clinical Trial
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Alleles
-
Animals
-
Base Sequence
-
Chromosomes, Human, Pair 11
-
Codon / genetics
-
DNA Primers
-
Genetic Carrier Screening
-
Genetic Linkage
-
Glycine
-
Hominidae / genetics*
-
Humans
-
Long QT Syndrome / genetics*
-
Molecular Sequence Data
-
Polymerase Chain Reaction
-
Polymorphism, Genetic*
-
Potassium Channels / genetics*
-
Potassium Channels, Voltage-Gated*
-
Serine
Substances
-
Codon
-
DNA Primers
-
Potassium Channels
-
Potassium Channels, Voltage-Gated
-
potassium channel protein I(sk)
-
Serine
-
Glycine