Abstract
Rates of drug-induced gastrointestinal bleeding were estimated from data on 16 646 consecutively monitored medical inpatients who had no known predisposing illness. Heparin, warfarin, ethacrynic acid, steroids, and aspirin-containing drugs were associated with gastrointestinal bleeding and were estimated to account for about two-thirds of such bleeds. Major gastrointestinal bleeding, defined as bleeding severe enough to require transfusion, occurred in only 57 patients (0.3%).
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anticoagulants / adverse effects*
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Aspirin / adverse effects*
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Chlordiazepoxide / adverse effects
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Drug Therapy, Combination
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Ethacrynic Acid / adverse effects*
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Gastrointestinal Hemorrhage / chemically induced*
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Gastrointestinal Hemorrhage / epidemiology
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Glucocorticoids / adverse effects*
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Heparin / adverse effects
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Humans
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Nitrofurantoin / adverse effects
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Warfarin / adverse effects
Substances
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Anticoagulants
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Glucocorticoids
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Warfarin
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Chlordiazepoxide
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Heparin
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Nitrofurantoin
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Ethacrynic Acid
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Aspirin