Microbial multidrug-resistance ABC transporters

Trends Microbiol. 1994 Oct;2(10):407-11. doi: 10.1016/0966-842x(94)90620-3.

Abstract

Multidrug resistance in tumor cells is often caused by the increased efflux of a wide variety of drugs, mediated by P glycoprotein, a member of the superfamily of ATP-binding cassette (ABC) transporters. The genes encoding members of this superfamily have also been isolated from drug-resistant microorganisms, and the role of microbial ABC transporters in drug resistance is being investigated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / physiology*
  • Animals
  • Bacteria / genetics
  • Drug Resistance, Multiple / genetics
  • Drug Resistance, Multiple / physiology*
  • Humans
  • Leishmania / genetics
  • Mice
  • Neoplasms / physiopathology
  • Plasmodium / genetics
  • Yeasts / genetics

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • ATP-Binding Cassette Transporters