Serum gastrin levels and colorectal neoplasia

Dis Colon Rectum. 1995 Feb;38(2):172-6. doi: 10.1007/BF02052446.

Abstract

Purpose: Confirmation of an association between elevated serum gastrin concentrations and presence of colorectal tumors would have important implications with regard to screening procedures and therapeutic strategies.

Methods: We compared fasting serum gastrin concentrations of patients with colorectal cancer (n = 91; mean age, 66 (range, 35-87) years), colorectal polyps (n = 89; mean age, 61 (range, 38-86) years), or a normal colonoscopy (n = 101; mean age, 62 (range, 34-82) years) in the period between 1983 and 1992.

Results: Median serum gastrin concentrations were, respectively, 20, 20, and 21 pmol/liter (not significant). We were unable to find a relation with histology of the polyp, presence or severity of dysplasia, and extent of cancer.

Conclusions: This large study fails to show any difference in serum gastrin concentrations among the three studied groups.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / blood*
  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Aged, 80 and over
  • Colonic Polyps / blood*
  • Colonic Polyps / pathology
  • Colonoscopy
  • Colorectal Neoplasms / blood*
  • Colorectal Neoplasms / pathology
  • Female
  • Gastrins / blood*
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Retrospective Studies

Substances

  • Gastrins