Abstract
Using the recent burgeoning of information on how the stress response systems interact, and combining this with advances in our understanding of neuroimmune communication, a proposed neuroendocrine-neuroimmune stress response system incorporating autoimmunoregulation is reviewed. The study of immunocyte behavior in certain clinical conditions associated with a variant stress response may help illuminate the functioning of the neuroendocrine-neuroimmune stress response system.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Corticotropin-Releasing Hormone / physiology
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Cytokines / physiology
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Depression / physiopathology
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Endorphins / physiology
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General Adaptation Syndrome / physiopathology*
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Homeostasis
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Humans
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Hypothalamo-Hypophyseal System / physiopathology
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Immunity, Cellular
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Immunologic Deficiency Syndromes / etiology
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Immunologic Deficiency Syndromes / physiopathology
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Limbic System / physiopathology
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Locus Coeruleus / physiopathology
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Lymphocyte Subsets / immunology
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Models, Biological
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Neuroimmunomodulation*
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Neurotransmitter Agents / physiology
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Paraventricular Hypothalamic Nucleus / physiopathology
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Pituitary-Adrenal System / physiopathology
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Stress, Physiological / complications
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Stress, Physiological / immunology*
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Stress, Physiological / physiopathology
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Sympathetic Nervous System / physiopathology
Substances
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Cytokines
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Endorphins
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Neurotransmitter Agents
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Corticotropin-Releasing Hormone