A high proportion of recent human rabies cases diagnosed in the United States have been acquired outside the country and have lacked a history of animal bite exposure. On June 21, 1994, a 40-year-old man died in a hospital in Miami following a subacute and progressive neurologic syndrome; rabies had not been clinically suspected but was diagnosed postmortem on July 13. This report summarizes the case investigation, which indicated that the case was acquired outside the United States.