Klebsiella bacteraemia: a report of 101 cases from National University Hospital, Singapore

J Hosp Infect. 1994 Aug;27(4):299-305. doi: 10.1016/0195-6701(94)90117-1.

Abstract

One hundred and one cases of Klebsiella bacteraemia from the National University Hospital, Singapore, were reviewed retrospectively. There were 54 (53.5%) males and 47 (46.5%) females. Mean (+/- SE) age was 54 (+/- 2.4) years. Overall mortality was 26%. Nosocomial infections accounted for 20%. Underlying diabetes mellitus and malignancy were present in 36 and 26% respectively. The source of the bacteraemia was not known in 33% of cases, 17% had liver abscess, 29% had urinary tract infections, 9% had pneumonia, 10% had an abscess separate from the liver, and 3% had biliary sepsis. Elevated alkaline phosphatase (> 100 U-1) was seen in all cases of liver abscess (sensitivity 100%, specificity 27%). Nonsurvivors had a significantly lower platelet count than survivors (104 +/- 25 x 10(9)/l vs. 176 +/- 15 x 10(9)/l, unpaired t-test P < 0.05), and a platelet count of less than 150 x 10(9)/l was associated with a significantly higher mortality (37% vs. 11%, chi 2 P < 0.01). Nosocomial infection was associated with 45% mortality, whereas community-acquired infection had a lower rate of 21%, this was not statistically significant. Seventy-eight per cent of these Klebsiella isolates were sensitive to gentamicin and cotrimoxazole, and 100% to imipenem.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / epidemiology*
  • Bacteremia / etiology
  • Cross Infection / epidemiology*
  • Cross Infection / etiology
  • Diabetes Complications
  • Female
  • Hospitals, University
  • Humans
  • Klebsiella Infections / epidemiology*
  • Klebsiella Infections / etiology
  • Liver Abscess / complications
  • Male
  • Middle Aged
  • Neoplasms / complications
  • Pneumonia / complications
  • Retrospective Studies
  • Singapore / epidemiology

Substances

  • Anti-Bacterial Agents