The PACAP receptor: generation by alternative splicing of functional diversity among G protein-coupled receptors in nerve cells

Semin Cell Biol. 1994 Aug;5(4):263-72. doi: 10.1006/scel.1994.1032.

Abstract

Recent molecular characterization of new G protein-coupled receptors (GPCR) draw attention to alternative splicing as a source of structural diversity. After a brief overview of characterized GPCR splice variants, we will describe in more detail the functional properties of the PACAP type I receptor splice variants. Some of these variants are positively coupled to both adenylate cyclase (AC) and phospholipase C (PLC) whereas others do not elicit any stimulation of the PLC or display a qualitatively intermediate phenotype. The PACAP type I receptor is therefore one of the few examples in which alternative splicing is clearly linked to functional diversity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing*
  • Amino Acid Sequence
  • Animals
  • GTP-Binding Proteins / physiology*
  • Humans
  • Molecular Sequence Data
  • Neurons / physiology*
  • Receptors, Cell Surface / physiology*
  • Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
  • Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
  • Receptors, Pituitary Hormone / chemistry
  • Receptors, Pituitary Hormone / physiology*

Substances

  • Receptors, Cell Surface
  • Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
  • Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
  • Receptors, Pituitary Hormone
  • GTP-Binding Proteins