Abstract
The transcription factor NF-ATp is a target in activated T cells for the calcium-regulated phosphatase calcineurin, and is therefore a secondary target for the immunosuppressive drugs cyclosporin A and FK506. Here, Anjana Rao describes how NF-ATp cooperates with Fos- and Jun-family proteins to mediate transcription of the interleukin 2 gene, and how it may participate in the calcium-dependent transcription of other cytokine genes in several types of immune-system cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Base Sequence
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Cytokines / genetics*
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Cytokines / metabolism
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Gene Expression Regulation
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Genes, fos
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Genes, jun
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Molecular Sequence Data
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NFATC Transcription Factors
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Phosphoproteins / genetics
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Phosphoproteins / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Cytokines
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DNA-Binding Proteins
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NFATC Transcription Factors
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Nuclear Proteins
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Phosphoproteins
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Transcription Factors