Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping

B Crouau-Roy; C Amadou; C Bouissou; J Clayton; C Vernet; M T Ribouchon; P Pontarotti

doi:10.1006/geno.1994.1249

Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping

Genomics. 1994 May 1;21(1):241-3. doi: 10.1006/geno.1994.1249.

Authors

B Crouau-Roy¹, C Amadou, C Bouissou, J Clayton, C Vernet, M T Ribouchon, P Pontarotti

Affiliation

¹ CRPG CNRS, UPR 8291, CHU Purpan, Toulouse, France.

PMID: 8088794
DOI: 10.1006/geno.1994.1249

Abstract

OTF3 (octamer transcription factor 3) is a transcription factor containing a POU-specific domain and a homeodomain that could play a role in early development. In situ hybridization and pairwise linkage analysis showed that OTF3 gene maps close to the human MHC (major histocompatibility complex). In this paper, we define its localization within the MHC, around 100 kb telomeric to HLA-C, using a combination of physical and genetic analyses.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Chromosome Mapping / methods
Chromosomes, Artificial, Yeast
Crossing Over, Genetic
DNA-Binding Proteins / genetics*
Embryonic and Fetal Development / genetics
Genes
Haplotypes / genetics
Humans
In Situ Hybridization
Major Histocompatibility Complex*
Meiosis
Octamer Transcription Factor-3
Transcription Factors / genetics*

Substances

DNA-Binding Proteins
Octamer Transcription Factor-3
POU5F1 protein, human
Transcription Factors