The effect of short term lithium treatment on the leukocyte, liver and muscle carbohydrate metabolism of guinea-pigs

Gen Pharmacol. 1993 Nov;24(6):1491-3. doi: 10.1016/0306-3623(93)90441-y.

Abstract

1. The effect of lithium treatment on the leukocyte, liver and muscle glycogen levels of guinea-pigs has been studied. 2. A 4-week treatment with lithium chloride (5 mmol/l i.p. in saline) increased leukocyte, liver and muscle glycogen and decreased blood glucose levels. 3. These results strongly suggest that a lithium-induced insulin-like effect may be related to the long term effect.

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Carbohydrate Metabolism*
  • Glycogen / metabolism
  • Guinea Pigs
  • Leukocytes / drug effects
  • Leukocytes / metabolism*
  • Lithium / pharmacology*
  • Liver / drug effects
  • Liver / metabolism*
  • Liver Glycogen / metabolism
  • Male
  • Muscles / drug effects
  • Muscles / metabolism*

Substances

  • Blood Glucose
  • Liver Glycogen
  • Glycogen
  • Lithium