Abstract
Ten new delta6a,10a-THC analogs with arylalkyl side chains, one with a dimethylaminoalkyl side chain, and six heterocyclic delta6a,10a-THC analogs [8-substituted 5,5-dimethyl-10-hydroxy-2-(2-propynyl)-1,2,3,4-tetrahydro-5H-[1]benzo-pyrano[4,3-c]pyridines] were prepared. They showed pharmacological activity as analgesics, tranquilizers, antihypertensives, and hypnotics and as antisecretory, antiulcer, and antidiarrheal agents. The most potent compounds had either a 1-methyl-4-(4-fluorophenyl)butyl or a 1,2-dimethyl-4-(4-fluorophenyl)butyl side chain.
MeSH terms
-
Aggression / drug effects
-
Analgesics
-
Animals
-
Anticonvulsants
-
Antidepressive Agents
-
Antidiarrheals
-
Antihypertensive Agents
-
Ataxia / chemically induced
-
Blood Pressure / drug effects
-
Cannabis / chemical synthesis*
-
Cats
-
Dogs
-
Dronabinol / analogs & derivatives
-
Dronabinol / chemical synthesis*
-
Dronabinol / pharmacology
-
Gastric Mucosa / metabolism
-
Haplorhini
-
Humans
-
Hypnotics and Sedatives
-
Male
-
Mice
-
Motor Activity / drug effects
-
Rats
-
Sleep / drug effects
-
Stomach Ulcer / prevention & control
-
Structure-Activity Relationship
-
Tranquilizing Agents
Substances
-
Analgesics
-
Anticonvulsants
-
Antidepressive Agents
-
Antidiarrheals
-
Antihypertensive Agents
-
Hypnotics and Sedatives
-
Tranquilizing Agents
-
Dronabinol