1,3-Diarylindan-2-carboxylic acids, potent and selective non-peptide endothelin receptor antagonists

J Med Chem. 1994 May 27;37(11):1553-7. doi: 10.1021/jm00037a003.

Authors

J D Elliott¹, M A Lago, R D Cousins, A Gao, J D Leber, K F Erhard, P Nambi, N A Elshourbagy, C Kumar, J A Lee, et al.

Affiliation

¹ Research and Development Division, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.

PMID: 8201588
DOI: 10.1021/jm00037a003

No abstract available

MeSH terms

Amino Acid Sequence
Animals
Endothelin Receptor Antagonists*
Endothelins / chemistry
Endothelins / physiology
Indans / chemical synthesis*
Indans / metabolism
Indans / pharmacology
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Molecular Sequence Data
Rats
Receptors, Endothelin / metabolism

Substances

Endothelin Receptor Antagonists
Endothelins
Indans
Receptors, Endothelin
1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)-