A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme

K Kok; R Hofstra; A Pilz; A van den Berg; P Terpstra; C H Buys; B Carritt

doi:10.1073/pnas.90.13.6071

A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme

Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6071-5. doi: 10.1073/pnas.90.13.6071.

Authors

K Kok¹, R Hofstra, A Pilz, A van den Berg, P Terpstra, C H Buys, B Carritt

Affiliation

¹ Department of Medical Genetics, University of Groningen, The Netherlands.

Abstract

The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
Chromosomes, Human, Pair 3*
DNA / chemistry
Genes, Tumor Suppressor*
Humans
Ligases / genetics*
Lung Neoplasms / genetics*
Molecular Sequence Data
Sequence Homology, Nucleic Acid
Ubiquitin-Activating Enzymes
Ubiquitin-Protein Ligases

Substances

DNA
Ubiquitin-Protein Ligases
Ligases
Ubiquitin-Activating Enzymes

Associated data

GENBANK/L13852