An improved method for O-demethylation of codeine

J Med Chem. 1977 Jan;20(1):165-6. doi: 10.1021/jm00211a037.

Abstract

The O-demethylation of codeine was effected by sodium propylmercaptide in dimethylformamide at 125 degrees C to afford morphine in 80% yield. Similar treatment of thebaine was unrewarding.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Codeine*
  • Methylation
  • Morphine / chemical synthesis
  • Sulfhydryl Compounds
  • Temperature
  • Thebaine

Substances

  • Sulfhydryl Compounds
  • Thebaine
  • Morphine
  • Codeine