Abstract
The O-demethylation of codeine was effected by sodium propylmercaptide in dimethylformamide at 125 degrees C to afford morphine in 80% yield. Similar treatment of thebaine was unrewarding.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Codeine*
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Methylation
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Morphine / chemical synthesis
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Sulfhydryl Compounds
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Temperature
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Thebaine
Substances
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Sulfhydryl Compounds
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Thebaine
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Morphine
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Codeine