Isoniazid-associated psychosis: case report and review of the literature

Ann Pharmacother. 1993 Feb;27(2):167-70. doi: 10.1177/106002809302700205.

Abstract

Objective: To describe a case of isoniazid-associated psychosis and review the incidence of this adverse effect.

Data sources: Information about the patient was obtained from the medical chart. A MEDLINE search of the English-language literature published from 1950 to 1992 was conducted and Index Medicus was manually searched for current information.

Study selection: All case reports describing isoniazid-associated psychosis were reviewed.

Data extraction: Studies were evaluated for the use of isoniazid, symptoms of psychosis, onset of symptoms, and dosage of isoniazid.

Data synthesis: The case report is compared with others reported in the literature. The incidence of isoniazid-associated psychosis is rare.

Conclusions: The mechanism of isoniazid-associated psychosis is uncertain. It appears that isoniazid was associated with the psychosis evident in our patient and in the cases reviewed.

Publication types

  • Case Reports
  • Comparative Study
  • Review

MeSH terms

  • Aged
  • Humans
  • Incidence
  • Isoniazid / adverse effects*
  • Male
  • Psychoses, Substance-Induced / etiology*

Substances

  • Isoniazid