Abstract
A 39 year-old man with malaria due to Plasmodium falciparum received 3500 mg mefloquine over 3 days, in addition to 3250 mg chloroquine and 175/3500 mg sulfadoxine/pyrimethamine. He developed severe neuropsychiatric symptoms and had to be hospitalized. Treatment with diazepam, haloperidol and thioridazine achieved relief of the severe symptoms after 4 days. The patient was still suffering from discrete neuropsychiatric symptoms 8 months after treatment.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Diazepam / administration & dosage
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Drug Therapy, Combination
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Haloperidol / administration & dosage
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Humans
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Malaria, Falciparum / drug therapy*
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Male
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Mefloquine / administration & dosage
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Mefloquine / poisoning*
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Psychoses, Substance-Induced / drug therapy
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Psychoses, Substance-Induced / etiology*
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Pyrimethamine / administration & dosage
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Pyrimethamine / poisoning*
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Sulfadoxine / administration & dosage
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Sulfadoxine / poisoning*
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Thioridazine / administration & dosage
Substances
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Sulfadoxine
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Haloperidol
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Thioridazine
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Diazepam
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Mefloquine
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Pyrimethamine