Abstract
The understanding of actin structure and function has been improved by comparing the atomic structure of G-actin, the model of the F-actin structure, and the properties of actin mutants. Several aspects of actin structure have been tested and good progress has been made in mapping its myosin-binding sites. The dynamic properties of actin and genetic evaluation of its cellular function are attracting increasing attention.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Actins / chemistry*
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Actins / genetics
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Actins / physiology
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Animals
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Bacterial Proteins / metabolism
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Binding Sites
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Calmodulin-Binding Proteins / metabolism
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Cell Movement
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Fungal Proteins / chemistry
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Fungal Proteins / genetics
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Microfilament Proteins / metabolism
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Muscle Contraction
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Myosins / metabolism
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Protein Binding
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Protein Conformation
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Structure-Activity Relationship
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Tropomyosin / metabolism
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Troponin / metabolism
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Troponin I
Substances
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Actins
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Bacterial Proteins
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Calmodulin-Binding Proteins
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Fungal Proteins
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Microfilament Proteins
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Tropomyosin
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Troponin
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Troponin I
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Myosins