The base excision repair pathway

Trends Biochem Sci. 1995 Oct;20(10):391-7. doi: 10.1016/s0968-0004(00)89086-6.

Abstract

The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating agents, which are similar to those induced by endogenous factors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenine
  • Alkylation
  • Amino Acid Sequence
  • Base Composition
  • Cytosine
  • DNA Damage
  • DNA Repair*
  • Endodeoxyribonucleases
  • Hydrolysis
  • Models, Genetic*
  • Molecular Sequence Data
  • N-Glycosyl Hydrolases
  • Purines
  • Uracil

Substances

  • Purines
  • Uracil
  • Cytosine
  • Endodeoxyribonucleases
  • N-Glycosyl Hydrolases
  • Adenine
  • purine