Fatal hyalohyphomycosis following Fusarium onychomycosis in an immunocompromised patient

Am J Dermatopathol. 1996 Apr;18(2):196-8. doi: 10.1097/00000372-199604000-00014.

Abstract

A 35-year-old man with B lymphoblastic lymphoma was treated with bone marrow transplant and aggressive chemotherapy. He developed a Fusarium infection of the great toenail. Septicemic dissemination of a Fusarium sp. occurred 9 months later during a lymphoma relapse. The clinical course of the hyalohyphomycosis was then rapidly fatal despite institution of amphotericin B therapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Bone Marrow Transplantation
  • Fatal Outcome
  • Foot Dermatoses / drug therapy
  • Foot Dermatoses / pathology
  • Fungemia / drug therapy
  • Fungemia / microbiology
  • Fusarium* / isolation & purification
  • Humans
  • Immunocompromised Host*
  • Lymphoma, B-Cell / drug therapy
  • Lymphoma, B-Cell / therapy
  • Male
  • Mycoses / drug therapy
  • Mycoses / pathology*
  • Neoplasm Recurrence, Local
  • Onychomycosis / drug therapy
  • Onychomycosis / pathology*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy

Substances

  • Antifungal Agents
  • Antineoplastic Agents
  • Amphotericin B