Abstract
An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blastomeres / transplantation
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Cell Polarity
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DNA Primers
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DNA, Complementary
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Digestive System / embryology
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Embryonic Induction* / physiology
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Embryonic Induction* / radiation effects
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Endoderm / physiology
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Gastrula / physiology*
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Head / embryology*
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In Situ Hybridization
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Intercellular Signaling Peptides and Proteins
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Mesoderm / physiology
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Molecular Sequence Data
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Proteins / genetics*
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Proteins / metabolism
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Proteins / physiology
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RNA, Messenger / metabolism
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Tail / embryology
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Ultraviolet Rays
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Xenopus
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Xenopus Proteins
Substances
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DNA Primers
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DNA, Complementary
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Intercellular Signaling Peptides and Proteins
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Proteins
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RNA, Messenger
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Xenopus Proteins
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cer1 protein, Xenopus