The GABAB receptor antagonist CGP 36,742 and the nootropic oxiracetam facilitate the formation of long-term memory

C Mondadori; H J Möbius; J Borkowski

doi:10.1016/0166-4328(95)00222-7

The GABAB receptor antagonist CGP 36,742 and the nootropic oxiracetam facilitate the formation of long-term memory

Behav Brain Res. 1996 May;77(1-2):223-5. doi: 10.1016/0166-4328(95)00222-7.

Authors

C Mondadori¹, H J Möbius, J Borkowski

Affiliation

¹ Pharmaceutical Research Department, CIBA Ltd., Basel, Switzerland. cesaremondadori@mmd.com

PMID: 8762175
DOI: 10.1016/0166-4328(95)00222-7

Abstract

The memory-enhancing effects of a single treatment with the GABAB antagonist CGP 36,742 (10 mg/kg) or the nootropic agent oxiracetam (100 mg/kg) given immediately after a learning experience ('post-trial') remain detectable for at least 4 months thereafter. This indicates that in all probability these substances facilitate the formation of the long-term memory trace.

MeSH terms

Animals
Brain / drug effects
Dose-Response Relationship, Drug
Female
GABA Antagonists / pharmacology*
Long-Term Potentiation / drug effects*
Mental Recall / drug effects*
Mice
Mice, Inbred Strains
Nootropic Agents / pharmacology*
Organophosphorus Compounds / pharmacology*
Pyrrolidines / pharmacology*
Receptors, GABA-B / drug effects*

Substances

GABA Antagonists
Nootropic Agents
Organophosphorus Compounds
Pyrrolidines
Receptors, GABA-B
(3-aminopropyl)(n-butyl)phosphinic acid
oxiracetam